Learn About These Medications for Bipolar Disorder

Bipolar Medication

Understanding Your Bipolar Medication Options

Every day we take bipolar medication (or medications) several times a day as directed by our doctor, hoping for the best result. In a perfect world, the expected results would quickly manifest, alleviating us from our symptoms and allowing us to go on with our lives. But the real world is not perfect, and doctors can spend months, even years, finding the right combination of drugs for each patient.

The process can be long and drawn out in some part because the process is not an exact science. Simply put, even the best doctor cannot predict how a patient will react to a medication.

As more drugs are added to the cocktail, the process gets more complicated and even less predictable. So most of us will experience ongoing changes in our medications.

If you have bipolar, your cocktail generally consists of three types of drugs: mood stabilizers, antidepressants, and antipsychotics. Let’s take a look at the options for each.

Mood Stabilizers

Mood stabilizers are drugs that help keep you steady, avoiding both the highs and lows of the illness. The primary mood stabilizers are:


Unlike other psychotropic drugs, lithium is derived from nature and is not created in a laboratory. It is a widely used drug, but because it is technically a salt, you must drink plenty of water and stay hydrated. While my doctors did not encourage a low-salt diet, they did state that I should not dramatically increase or decrease my salt intake while on lithium.


When taking lithium, it is important to have your lithium level checked via a blood test. If your lithium level is too low, you will not get the full benefit of the drug. If your lithium level is too high, it can be toxic.

Common side effects of lithium may include dry mouth, mild tremors (shakiness), weakness and diarrhea. Lithium consumption has also been associated with an underactive thyroid, so it is important also to monitor your thyroid function. If your tremors become severe or if you have other side effects, contact your physician.

Depakote (valporic acid)

Depakote was as originally patented as an anticonvulsant medication for seizures. It has been widely used for bipolar disorder since the early 1980s and surpassed lithium as the most used mood stabilizer in the 1990s.

Taking Depakote can damage your kidneys, so it is important to monitor your blood creatinine levels on a regular basis.

Common side effects for Depakote may include:

  • Gastrointestinal issues like upset stomach, diarrhea, and constipation.
  • Mild tremors (shakiness)
  • Weakness
  • Drowsiness
  • Hair loss.

If these side effects become severe or if you experience other side effects, contact your physician.

Lamictal (lamotrigine)

Like Depakote, Lamictal was also used as an anticonvulsant medication for seizures. It was introduced for use in bipolar patients around 2003.

Lamictal has been demonstrated to be especially useful when given to patients experiencing bipolar depression. Common side effects may include:

  • Mild tremors (shakiness)
  • Blurred vision
  • Dry mouth
  • Upset stomach
  • Changes in menstrual periods
  • Back pain

The most important thing to remember when taking Lamictal is that it can induce the Steven-Johnsons syndrome, an adverse reaction that causes a dangerous rash. If you experience any type of rash when using Lamictal, see a physician immediately.

Equetro, Tegretol (carbamazepine)

Carbamazepine also originated as an anticonvulsant but was approved for use in bipolar patients in 2005.


Antidepressants are one of the most prescribed drug classes in all of the medicine, so there are many choices. However, researchers have noted differences in the treatment of bipolar depression versus unipolar depression.

Generally speaking, some medications are not as effective in bipolar patients, giving them fewer choices. Many antidepressants are indicated for OCD (obsessive-compulsive disorder), eating disorders and other conditions. The following is a review of the different sub-classes of antidepressants.

Common side effects of antidepressants include:

  • Drowsiness
  • Nausea
  • Dry mouth
  • Insomnia
  • Anxiety
  • Diarrhea
  • Dizziness
  • Sexual problems including reduced sexual desire and erectile dysfunction.

If these side effects escalate or if you experience different side effects, see a physician immediately.

One important note of caution, you should never abruptly stop taking an antidepressant unless under direct order from a physician. Even then, ask your doctor about tapering you off of the medication instead of suddenly stopping your medication. In some cases stopping your medication, “cold turkey” can lead to extreme mood swings and in some instances, it leads to suicidal thoughts and behaviors.

Tricyclic Antidepressants

TCAs were developed and marketed in the 1950s. The goal of the TCA is to increase the amount of neurotransmitters like serotonin and noradrenaline.

However, TCAs work differently than SSRIs and SSNIs. These drugs prevent the neurotransmitters from binding to specific receptors on the nerves where they build up in between the nerve cells. This allows the neurotransmitter levels to increase.

Common TCAs include:

  • Amitriptyline
  • Amoxapine
  • Desipramine (Norpramin)
  • Doxepin
  • Imipramine (Tofranil)
  • Nortriptyline (Pamelor)
  • Protriptyline (Vivactil)
  • Trimipramine (Surmontil)

Monoamine Oxidase Inhibitors

MAOIs were introduced in the late 1950s and used up into the 1970s. These drugs inhibit the activity of the monoamine oxidase enzyme family. Because of potentially lethal dietary and medication interactions, MAOIs are now reserved as a last line of treatment, used only when other classes of antidepressant drugs have failed.

MAOIs include:

  • Isocarboxazid (Marplan)
  • Phenelzine (Nardil)
  • Tranylcypromine (Parnate)

Tetracyclic Antidepressants

TeCAs came on the market in the 1970s. They are similar to TCAs in that they increase the neurotransmitter levels; however, unlike TCAs, which have three rings on the atomic level, tetracyclic antidepressants have four rings.

  • Amoxapine (Asendin)
  • Maprotiline (Ludiomil)
  • Mianserin (Bolvidon, Norval, Tolvon)
  • Mirtazapine (Remeron)
  • Setiptiline (Tecipul)

Selective Serotonin Reuptake Inhibitors (SSRI)

SSRIs are designed to increase the level of the neurotransmitter serotonin. This is done by limiting its reabsorption into a specific type of cell, which then increases the level of serotonin in other cells so it can bind to the desired receptors.

SSRIs became available in the 1980s and are the most widely used antidepressants. However, for some bipolar patients SSRI drugs can induce manic symptoms, so you if you take these drugs you need to be aware of this tendency. Common SSRIs include:

  • Celexa (Citalopram)
  • Lexapro, Cipralex (Escitalopram)
  • Paxil, Seroxat (Paroxetine)
  • Prozac (Fluoxetine)
  • Luvox (Fluvoxamine)
  • Zoloft, Lustral (Sertraline)

Next page: more antidepressants and other bipolar medication options that are available to you. 

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